Nanoha Takamachi is a 3rd grade elementary school girl. She lives with her parents who run a coffee shop, and her older sister and brother who are in high school and university respectively. Nanoha's regular life changes when she hears a voice calling to her on the way home and ends up rescuing an injured ferret (who is actually a transformed boy called Yūno, an archaeologist from a distant world). She obtains a magical crystal called Raising Heart (レイジングハート, Reijingu Hāto?), and gains magical powers.
After their encounter, Nanoha and Yūno have to collect the twenty-one "Jewel Seeds" (ジュエルシード, Jueru Shīdo?), powerful lost crystals from Yūno's world that grant wishes and are very dangerous when misused. However, Nanoha and Yūno are not the only ones after the Jewel Seeds. So is Fate Testarossa, a foreign girl with sad eyes...
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This series was much more epic then I had initially thought it would be and can be summed up as this. Little girls shooting large lasers using talking magical weaponry with a large amount of lesbian undertones.